Professor of Radiology
Body MRI Fellowship Director
Diagnostic Breast MRI:
Breast cancer is the second most lethal tumor among American women. Although x-ray mammography reduces breast cancer mortality, mammography does not detect all breast cancers. MRI is approximately twice as sensitive as x-ray mammography.
High-resolution dynamic contrast enhanced MRI with images every 10 seconds during the "wash-in" phase of contrast enhancement in a small invasive ductal carcinoma show very rapid initial enhancement.
Diagnostic prostate MRI:
Prostate cancer is the second most lethal tumor among American men. Although most prostate cancer is detected at an early stage, when confined to the Prost gland, many tumors are overdiagnosed, including purely low-grade tumors with low likelihood of clinical impact. other tumors are often underdiagnosed, including high-grade tumors which are missed by systematic, but non-image guided transrectal biopsy. at Stanford we are developing novel imaging sequences for improved contrast enhanced imaging and high-resolution diffusion imaging of localized prostate cancer, with a goal to ultimately enable targeted a biopsy and focal therapy.
T2-weighted imaging (left) of a man with extensive Gleason 3+4 tumor shows low signal thoughout the peripheral zone corresponding to tumor. Very high b-valued high-resolution DWI (right) image shows restricted diffusion in the same tumor compared to normal prostate.