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Liver Metastases

MRI is highly sensitive for the detection of both hypervascular and hypovascular liver metastases.  In particular MRI can be performed with Eovist, a contrast agent that is taken up by normal hepatocytes, providing a bright liver background against which small lesions can be detected.

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How to place an MRI request on Epic

Examples (click on images)

Liver metastases well delineated as dark lesions with Eovist.
Dynamic contrast enhancement shows rapid uptake and washout of contrast from carcinoid metastases to the liver.

References

  1. Muhi A, Ichikawa T, Motosugi U, et al. Diagnosis of colorectal hepatic metastases: comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI. J Magn Reson Imaging 2011; 34:326-335. PubMed link
  2. Hirashima Y, Yamada Y, Tateishi U, et al. Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis. Int J Cancer 2012; 130:2359-2365. PubMed link
  3. Sofue K, Tsurusaki M, Tokue H, Arai Y, Sugimura K. Gd-EOB-DTPA-enhanced 3.0 T MR imaging: quantitative and qualitative comparison of hepatocyte-phase images obtained 10 min and 20 min after injection for the detection of liver metastases from colorectal carcinoma. Eur Radiol 2011; 21:2336-2343. PubMed link
  4. Koh DM, Scurr E, Collins D, et al. Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients. AJR Am J Roentgenol 2007; 188:1001-1008. PubMed link
  5. Kamaya A, Maturen KE, Tye GA, Liu YI, Parti NN, Desser TS. Hypervascular liver lesions. Semin Ultrasound CT MR 2009; 30:387-407. PubMed link
  6. Bruegel M, Rummeny EJ. Hepatic metastases: use of diffusion-weighted echo-planar imaging. Abdom Imaging 2010; 35:454-461. PubMed link
  7. Cui Y, Zhang XP, Sun YS, Tang L, Shen L. Apparent diffusion coefficient: potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases. Radiology 2008; 248:894-900. PubMed link