Professor of Radiology
Body MRI Fellowship Director
(650) 725-1812

Clinical Interests

Diagnostic Breast MRI:

Breast cancer is the second most lethal tumor among American women. Although x-ray mammography reduces breast cancer mortality, mammography does not detect all breast cancers. MRI is approximately twice as sensitive as x-ray mammography.

DISCO high-resolution images every 10 seconds during the "wash-in" phase of contrast enhancement in a small invasive ductal carcinoma show very rapid initial enhancement.

High-resolution dynamic contrast enhanced MRI with images every 10 seconds during the "wash-in" phase of contrast enhancement in a small invasive ductal carcinoma show very rapid initial enhancement.

 

Diagnostic prostate MRI:

Prostate cancer is the second most lethal tumor among American men. Although most prostate cancer is detected at an early stage, when confined to the Prost gland, many tumors are overdiagnosed, including purely low-grade tumors with low likelihood of clinical impact. other tumors are often underdiagnosed, including high-grade tumors which are missed by systematic, but non-image guided transrectal biopsy. at Stanford we are developing novel imaging sequences for improved contrast enhanced imaging and high-resolution diffusion imaging of localized prostate cancer, with a goal to ultimately enable targeted a biopsy and focal therapy.

T2-weighted imaging of a man with extensive Gleason score 3+4=7 tumor shows low signal thoughout the peripheral zone corresponding to tumor.  Very high B-valued high-resolution DWI (right) image shows restricted diffusion in the same tumor compared to normal prosatate.

T2-weighted imaging (left) of a man with extensive Gleason 3+4 tumor shows low signal thoughout the peripheral zone corresponding to tumor. Very high b-valued high-resolution DWI (right) image shows restricted diffusion in the same tumor compared to normal prostate.

Research Overview

Dr. Daniel's research interests are Breast MRI & Interventional MRI.

Breast MRI:
At Stanford we have a large effort dedicated to improving MRI scanning techniques for breast cancer, including ultra rapid volumetric imaging of dynamic contrast enhancement, and novel diffusion weighted sequences for detecting breast cancer without contrast material.

Interventional MRI:
When focal abnormalities are detected in the breast, prostate, or other organs with MRI, and these abnormalities cannot be visualized with other methods, and MRI guided biopsy may be necessary to establish a diagnosis. Current MRI scanners however provide very limited access to the body for interventional procedures. We are developing a number of flexible approaches for minimally invasive procedures under MRI guidance, including freehand breast biopsy techniques, and remote manipulators that enable transperineal access to the prostate, in conjunction with the Department of mechanical engineering.

Last modified Fri, 7 Sep, 2012 at 19:51