MR Cholangiopancreatograpy with Secretin

Diagnosis of chronic pancreatitis can be challenging, and often relies on a combination of morphologic and functional tests. Secretin-enhanced MRCP is a non-invasive method of evaluating both pancreatic morphology and function that utilizes intravenously injected secretin to characterize the pancreatic ductal system and to stimulate pancreatic exocrine function.

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Coronal thick slab MRCP images demonstrate progressive filling of the duodenum after stimulation of the pancreas by secretin.
References
  1. Balci NC, Smith A, Momtahen AJ, et al. MRI and S-MRCP findings in patients with suspected chronic pancreatitis: correlation with endoscopic pancreatic function testing (ePFT). J Magn Reson Imaging 2010; 31:601-606. PubMed link
  2. Czako L. Diagnosis of early-stage chronic pancreatitis by secretin-enhanced magnetic resonance cholangiopancreatography. J Gastroenterol 2007; 42 Suppl 17:113-117. PubMed link
  3. Sanyal R, Stevens T, Novak E, Veniero JC. Secretin-enhanced MRCP: review of technique and application with proposal for quantification of exocrine function. AJR Am J Roentgenol 2012; 198:124-132. PubMed link
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